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JAMA. 2021;326(16):1624-1625. doi:10.1001/jama.2021.11604
JAMA. 2020;323(4):376-377. doi:10.1001/jama.2019.19127
Evidence suggests that greater than 70% of patients to whom oral iron is prescribed report significant gastrointestinal toxicity.
PLoS One. 2015;10(2):e0117383. doi:10. 1371/journal.pone.0117383
Reference ranges
( Ferritin: 13-126 ng/mL) (Iron: 37-145 μg/dL ) (Hemoglobin: 12.0-16.0, g/dL)
In premenopausal women, menstrual blood loss is leading cause of Iron deficiency anemia.
Very small risk of missing a gastrointestinal malignancy.
Reasonable to select an initial course of iron replacement therapy and no initial bidirectional endoscopy.
Patients who undergo gastric bypass have an obligate need for intravenous, not oral, iron.
Recently
ferritin cutoff increased to less than 45 ng/mL to diagnose Iron deficiency anemia.